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Combo-pilling is the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is now popular will be the fact that since right now there aren't any long term prescription weightloss pills that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure level and heartbeat, and mustn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. 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