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Recent research has discovered that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent have a particular mutation that creates them prone to benefit from naltrexone, compared with about 20% of Caucasians and much less than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director with the UCLA Addictions Laboratory. The findings are presently available online ( inside journal Neuropsychopharmacology and you will be published in the upcoming print edition from the journal. Using two separate drugs to shed pounds can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you ought to err assisting caution and let the FDA do its job and demand some research be done so that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on the medications. Researchers found out that participants investing in this drug for the year, lost weight within a month and have kept the weight off throughout the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them far better and safer. Combo-pilling is the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that as of right now there aren't long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. The drug may also raise blood pressure level and heartbeat, and shouldn't be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high hypertension, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed within the liver right after uptake in the intestines and has no therapeutic effect. Buprenorphine will be the active substance; it is absorbed underneath the tongue (and through the entire mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, the place that the first part of the intestine is bypassed and the stomach contents empty in a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy the place that the drug is taken up from the duodenum and transferred right to the liver by the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken up by servings of the intestine that aren't served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.