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Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err assisting caution and allow the FDA do its job and demand some research be done in order that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their medications. Researchers discovered that participants taking this drug for a year, lost excess weight within a month and have kept the weight off during the entire 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which are made up of many active ingredient, which may make them far better and safer. Combo-pilling could be the newest fad or also the newest in the future under scrutiny and so it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular will be the fact that by right now there are no long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartrate, and shouldn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure levels, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. The most common negative effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.